CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1280.10
Functional Family tRNA (guanine-N(1)-)-methyltransferase

Enzyme Information

2.1.1.228
tRNA (guanine(37)-N(1))-methyltransferase.
based on mapping to UniProt Q2GIL5
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.

UniProtKB Entries (1)

Q2GIL5
TRMD_ANAPZ
Anaplasma phagocytophilum str. HZ
TRNA (guanine-N(1)-)-methyltransferase

PDB Structure

PDB 3KNU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of tRNA (guanine-N1)-methyltransferase from Anaplasma phagocytophilum
Edwards, T.E., Abendroth, J., Stahl, G., Sankaran, B., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
To be Published