CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.660.10
Functional Family

Enzyme Information

1.6.3.5
Renalase.
based on mapping to UniProt Q888A4
(1) 1,2-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2). (2) 1,6-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2).
-!- Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta- NAD(P)(+). -!- These isomeric forms, generated by nonspecific reduction of beta- NAD(P)(+) or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.

UniProtKB Entries (1)

Q888A4
RNLS_PSESM
Pseudomonas syringae pv. tomato str. DC3000
Renalase

PDB Structure

PDB 3KKJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-ray structure of P. syringae q888a4 Oxidoreductase at resolution 2.5A, Northeast Structural Genomics Consortium target PsR10
Kuzin, A.P., Chen, Y., Forouhar, F., Vorobiev, S., Acton, T., Ma, L.C., Xiao, R., Montelione, G.T., Hunt, J.F., Tong, T.
To be Published