CATH Classification

Domain Context

CATH Clusters

Superfamily Umud Fragment, subunit A
Functional Family LexA repressor

Enzyme Information

3.4.21.88
Repressor LexA.
based on mapping to UniProt P0A7C2
Hydrolysis of Ala-|-Gly bond in repressor LexA.
-!- In the presence of single-stranded DNA, the RecA protein interacts with LexA causing an autocatalytic cleavage which disrupts the DNA- binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. -!- The activity was previously attributed to the RecA protein (formerly EC 3.4.99.37). -!- Belongs to peptidase family S24.

UniProtKB Entries (1)

P0A7C2
LEXA_ECOLI
Escherichia coli K-12
LexA repressor

PDB Structure

PDB 3JSO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the LexA-DNA complex and implications for SOS box measurement.
Zhang, A.P., Pigli, Y.Z., Rice, P.A.
Nature