CATH Classification

Domain Context

CATH Clusters

Superfamily arginine biosynthesis bifunctional protein suprefamily
Functional Family Arginine biosynthesis bifunctional protein ArgJ

Enzyme Information

2.3.1.1
Amino-acid N-acetyltransferase.
based on mapping to UniProt P9WPZ3
Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.
-!- Also acts with L-aspartate and, more slowly, with some other amino acids.
2.3.1.35
Glutamate N-acetyltransferase.
based on mapping to UniProt P9WPZ3
N(2)-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L- glutamate.
-!- Also has some hydrolytic activity on acetyl-L-ornithine, but the rate is 1% of that of transferase activity.

UniProtKB Entries (1)

P9WPZ3
ARGJ_MYCTU
Mycobacterium tuberculosis H37Rv
Arginine biosynthesis bifunctional protein ArgJ

PDB Structure

PDB 3IT4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The molecular structure of ornithine acetyltransferase from Mycobacterium tuberculosis bound to ornithine, a competitive inhibitor.
Sankaranarayanan, R., Cherney, M.M., Garen, C., Garen, G., Niu, C., Yuan, M., James, M.N.
J.Mol.Biol.