CATH Classification

Domain Context

CATH Clusters

Superfamily Pantoate-beta-alanine ligase, C-terminal domain
Functional Family Pantothenate synthetase

Enzyme Information

6.3.2.1
Pantoate--beta-alanine ligase (AMP-forming).
based on mapping to UniProt P9WIL5
ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.

UniProtKB Entries (1)

P9WIL5
PANC_MYCTU
Mycobacterium tuberculosis H37Rv
Pantothenate synthetase

PDB Structure

PDB 3IME
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase.
Hung, A.W., Silvestre, H.L., Wen, S., Ciulli, A., Blundell, T.L., Abell, C.
Angew.Chem.Int.Ed.Engl.