CATH Classification

Domain Context

CATH Clusters

Superfamily Enolase-like C-terminal domain
Functional Family Dipeptide epimerase

Enzyme Information

5.1.1.20
L-Ala-D/L-Glu epimerase.
based on mapping to UniProt Q8A861
L-alanyl-D-glutamate = L-alanyl-L-glutamate.
-!- The enzyme, characterized from the bacteria Escherichia coli and Bacillus subtilis, is involved in the recycling of the murein peptide, of which L-Ala-D-Glu is a component. -!- In vitro the enzyme from E.coli epimerizes several L-Ala-L-X dipeptides with broader specificity than the enzyme from B.subtilis. -!- Formerly EC 5.1.1.n1.

UniProtKB Entries (1)

Q8A861
AEEP_BACTN
Bacteroides thetaiotaomicron VPI-5482
L-Ala-D/L-Glu epimerase

PDB Structure

PDB 3IJQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily.
Lukk, T., Sakai, A., Kalyanaraman, C., Brown, S.D., Imker, H.J., Song, L., Fedorov, A.A., Fedorov, E.V., Toro, R., Hillerich, B., Seidel, R., Patskovsky, Y., Vetting, M.W., Nair, S.K., Babbitt, P.C., Almo, S.C., Gerlt, J.A., Jacobson, M.P.
Proc.Natl.Acad.Sci.USA