CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Cathepsin S

Enzyme Information

3.4.22.27
Cathepsin S.
based on mapping to UniProt P25774
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.
-!- A lysosomal cysteine endopeptidase that is unusual among such enzymes for its stability to neutral pH. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P25774
CATS_HUMAN
Homo sapiens
Cathepsin S

PDB Structure

PDB 3IEJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements.
Ameriks, M.K., Axe, F.U., Bembenek, S.D., Edwards, J.P., Gu, Y., Karlsson, L., Randal, M., Sun, S., Thurmond, R.L., Zhu, J.
Bioorg.Med.Chem.Lett.