CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1270.30
Functional Family

Enzyme Information

1.2.7.4
Anaerobic carbon-monoxide dehydrogenase.
based on mapping to UniProt P27989
CO + H(2)O + 2 oxidized ferredoxin = CO(2) + 2 reduced ferredoxin + 2 H(+).
-!- This prokaryotic enzyme catalyzes the reversible reduction of CO(2) to CO. -!- The electrons are transferred to redox proteins such as ferredoxin. -!- In purple sulfur bacteria and methanogenic archaea it catalyzes the oxidation of CO to CO(2), which is incorporated by the Calvin-Benson- Basham cycle or released, respectively. -!- In acetogenic and sulfate-reducing microbes it catalyzes the reduction of CO(2) to CO, which is incorporated into acetyl CoA by EC 2.3.1.169, with which the enzyme forms a tight complex in those organisms. -!- In purple sulfur bacteria the enzyme forms complexes with the Ni-Fe-S protein EC 1.12.7.2 which catalyze the overall reaction: CO + H(2)O = CO(2) + H(2). -!- Cf. EC 1.2.5.3. -!- Formerly EC 1.2.99.2.

UniProtKB Entries (1)

P27989
DCMB_MOOTH
Moorella thermoacetica
Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit beta

PDB Structure

PDB 3I01
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystallographic snapshots of cyanide- and water-bound C-clusters from bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase.
Kung, Y., Doukov, T.I., Seravalli, J., Ragsdale, S.W., Drennan, C.L.
Biochemistry