CATH Classification

Domain Context

CATH Clusters

Superfamily NagB/RpiA/CoA transferase-like
Functional Family 5-formyltetrahydrofolate cyclo-ligase

Enzyme Information

6.3.3.2
5-formyltetrahydrofolate cyclo-ligase.
based on mapping to UniProt P49914
ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10- methenyltetrahydrofolate.

UniProtKB Entries (1)

P49914
MTHFS_HUMAN
Homo sapiens
5-formyltetrahydrofolate cyclo-ligase

PDB Structure

PDB 3HY6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues
Wu, D., Li, Y., Song, G., Cheng, C., Zhang, R., Joachimiak, A., Shaw, N., Liu, Z.-J.
Cancer Res.