CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease H-like superfamily/Ribonuclease H
Functional Family

Enzyme Information

3.1.3.73
Adenosylcobalamin/alpha-ribazole phosphatase.
based on mapping to UniProt P9WLH5
(1) Adenosylcobalamin 5'-phosphate + H(2)O = coenzyme B12 + phosphate. (2) Alpha-ribazole 5'-phosphate + H(2)O = alpha-ribazole + phosphate.
-!- This enzyme catalyzes the last step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, characterized in Salmonella enterica. -!- It also participates in a salvage pathway that recycles cobinamide into adenosylcobalamin.
3.1.26.4
Ribonuclease H.
based on mapping to UniProt P9WLH5
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.

UniProtKB Entries (2)

P0AEX9
MALE_ECOLI
Escherichia coli K-12
Maltose/maltodextrin-binding periplasmic protein
P9WLH5
RNHPH_MYCTU
Mycobacterium tuberculosis H37Rv
Bifunctional protein Rv2228c

PDB Structure

PDB 3HST
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and functional characterization of an RNase HI domain from the bifunctional protein Rv2228c from Mycobacterium tuberculosis.
Watkins, H.A., Baker, E.N.
J.Bacteriol.