CATH Classification

Domain Context

CATH Clusters

Superfamily Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain
Functional Family Nicotinate dehydrogenase medium molybdopterin subunit

Enzyme Information

1.17.1.5
Nicotinate dehydrogenase.
based on mapping to UniProt Q0QLF1
Nicotinate + H(2)O + NADP(+) = 6-hydroxynicotinate + NADPH.
-!- The enzyme is capable of acting on a variety of nicotinate analogs to varying degrees, including pyrazine-2-carboxylate, pyrazine 2,3- dicarboxylate, trigonelline and 6-methylnicotinate. -!- The enzyme from Clostridium barkeri also possesses a catalytically essential, labile selenium that can be removed by reaction with cyanide. -!- Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. -!- Other enzymes involved in this pathway are EC 1.3.7.1, EC 3.5.2.18, EC 1.1.1.291, EC 5.4.99.4, EC 5.3.3.6, EC 4.2.1.85 and EC 4.1.3.32. -!- Formerly EC 1.5.1.13.

UniProtKB Entries (1)

Q0QLF2
NDLMS_EUBBA
Eubacterium barkeri
Nicotinate dehydrogenase large molybdopterin subunit

PDB Structure

PDB 3HRD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Mo-Se active site of nicotinate dehydrogenase
Wagener, N., Pierik, A.J., Ibdah, A., Hille, R., Dobbek, H.
Proc.Natl.Acad.Sci.USA