CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family Glutathione S-transferase P

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt P09211
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

P09211
GSTP1_HUMAN
Homo sapiens
Glutathione S-transferase P

PDB Structure

PDB 3HKR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: structure-thermodynamic relationships and thermal stability.
Quesada-Soriano, I., Parker, L.J., Primavera, A., Casas-Solvas, J.M., Vargas-Berenguel, A., Baron, C., Morton, C.J., Mazzetti, A.P., Lo Bello, M., Parker, M.W., Garcia-Fuentes, L.
Protein Sci.