CATH Classification

CATH Clusters

Superfamily Alpha carbonic anhydrase
Functional Family Alpha carbonic anhydrase 3

Enzyme Information

4.2.1.1
Carbonic anhydrase.
based on mapping to UniProt P00918
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P00918
CAH2_HUMAN
Homo sapiens
Carbonic anhydrase 2

PDB Structure

PDB 3HKQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
S-Glycosyl Primary Sulfonamides-A New Structural Class for Selective Inhibition of Cancer-Associated Carbonic Anhydrases
Lopez, M., Paul, B., Hofmann, A., Morizzi, J., Wu, Q., Charman, S.A., Innocenti, A., Vullo, D., Supuran, C.T., Poulsen, S.-A.
J.Med.Chem.