1 keywords

CATH Domain 3h81A02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.12 Lyase 2-enoyl-coa Hydratase; Chain A, domain 2
Homologous Superfamily 1.10.12.10 Lyase 2-enoyl-coa Hydratase, Chain A, domain 2

Domain Context

CATH Clusters

Superfamily Lyase 2-enoyl-coa Hydratase, Chain A, domain 2
Functional Family Probable enoyl-CoA hydratase, mitochondrial

Enzyme Information

4.2.1.17
Enoyl-CoA hydratase.
based on mapping to UniProt P9WNN9
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O.
-!- Acts in the reverse direction. -!- With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74).

UniProtKB Entries (1)

P9WNN9
ECHA8_MYCTU
Mycobacterium tuberculosis H37Rv
Probable enoyl-CoA hydratase echA8

PDB Structure

PDB 3H81
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Increasing the structural coverage of tuberculosis drug targets.
Baugh, L., Phan, I., Begley, D.W., Clifton, M.C., Armour, B., Dranow, D.M., Taylor, B.M., Muruthi, M.M., Abendroth, J., Fairman, J.W., Fox, D., Dieterich, S.H., Staker, B.L., Gardberg, A.S., Choi, R., Hewitt, S.N., Napuli, A.J., Myers, J., Barrett, L.K., Zhang, Y., Ferrell, M., Mundt, E., Thompkins, K., Tran, N., Lyons-Abbott, S., Abramov, A., Sekar, A., Serbzhinskiy, D., Lorimer, D., Buchko, G.W., Stacy, R., Stewart, L.J., Edwards, T.E., Van Voorhis, W.C., Myler, P.J.
Tuberculosis (Edinb)