CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase S8/S53 domain
Functional Family Proprotein convertase subtilisin/kexin type 9

Enzyme Information

3.4.21.-
Serine endopeptidases.
based on mapping to UniProt Q8NBP7

UniProtKB Entries (1)

Q8NBP7
PCSK9_HUMAN
Homo sapiens
Proprotein convertase subtilisin/kexin type 9

PDB Structure

PDB 3H42
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
From the Cover: A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates.
Chan, J.C., Piper, D.E., Cao, Q., Liu, D., King, C., Wang, W., Tang, J., Liu, Q., Higbee, J., Xia, Z., Di, Y., Shetterly, S., Arimura, Z., Salomonis, H., Romanow, W.G., Thibault, S.T., Zhang, R., Cao, P., Yang, X.P., Yu, T., Lu, M., Retter, M.W., Kwon, G., Henne, K., Pan, O., Tsai, M.M., Fuchslocher, B., Yang, E., Zhou, L., Lee, K.J., Daris, M., Sheng, J., Wang, Y., Shen, W.D., Yeh, W.C., Emery, M., Walker, N.P., Shan, B., Schwarz, M., Jackson, S.M.
Proc.Natl.Acad.Sci.USA