CATH Classification

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt Q5HJD7
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

Q5HJD7
LDH1_STAAC
Staphylococcus aureus subsp. aureus COL
L-lactate dehydrogenase 1

PDB Structure

PDB 3H3J
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of lactate dehydrogenase mutant (A85R) from staphylococcus aureus complexed with NAD and pyruvate
Ho, M.-C., Almo, S.C., Schramm, V.L.
To be Published