CATH Classification

Domain Context

CATH Clusters

Superfamily Rieske [2Fe-2S] iron-sulphur domain
Functional Family Cytochrome b-c1 complex subunit Rieske

Enzyme Information

1.10.2.2
Quinol--cytochrome-c reductase.
based on mapping to UniProt Q5ZLR5
Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H(+).
-!- The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain. -!- It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria. -!- The mammalian enzyme contains cytochromes b-562, b-566 and C(1), and a 2-iron ferredoxin. -!- Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non- cytoplasmic compartment (cf. EC 1.6.99.3).

UniProtKB Entries (1)

D0VX28
D0VX28_CHICK
Gallus gallus
Cytochrome b-c1 complex subunit 6

PDB Structure

PDB 3H1L
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc(1) complex.
Berry, E.A., Huang, L.S., Lee, D.W., Daldal, F., Nagai, K., Minagawa, N.
Biochim.Biophys.Acta