CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family (S)-hydroxynitrile lyase

Enzyme Information

3.1.1.78
Polyneuridine-aldehyde esterase.
based on mapping to UniProt Q9SE93
Polyneuridine aldehyde + H(2)O = 16-epivellosimine + CO(2) + methanol.
-!- Following hydrolysis of this indole alkaloid ester, the carboxylic acid decarboxylates spontaneously giving the sarpagan skeleton. -!- Also acts on akuammidine aldehyde (the 16-epimer of polyneuridine aldehyde).

UniProtKB Entries (1)

Q9SE93
PNAE_RAUSE
Rauvolfia serpentina
Polyneuridine-aldehyde esterase

PDB Structure

PDB 3GZJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis and enzymatic mechanism of the biosynthesis of C9- from C10-monoterpenoid indole alkaloids
Yang, L., Hill, M., Wang, M., Panjikar, S., Stockigt, J.
Angew.Chem.Int.Ed.Engl.