CATH Classification

Domain Context

CATH Clusters

Superfamily Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family

Enzyme Information

2.3.1.161
Lovastatin nonaketide synthase.
based on mapping to UniProt Q9Y7D0
9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + holo-[lovastatin nonaketide synthase] = dihydromonacolin L-[lovastatin nonaketide synthase] + 9 CoA + 9 CO(2) + 11 NADP(+) + S-adenosyl-L-homocysteine + 6 H(2)O.
-!- This fungal enzyme system comprises a multi-functional polyketide synthase (PKS) and an enoyl reductase. -!- The PKS catalyzes many of the chain building reactions of EC 2.3.1.85, as well as a reductive methylation and a Diels-Alder reaction, while the reductase is responsible for three enoyl reductions that are necessary for dihydromonacolin L acid production.

UniProtKB Entries (1)

Q9Y7D0
LOVC_ASPTE
Aspergillus terreus
Lovastatin nonaketide synthase, enoyl reductase component

PDB Structure

PDB 3GQV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
biosynthesis of Lovastatin: Crystal structure and biochemical studies of LOVC, A trans-acting polyketide enoyl reductase
Ames, B.D., Smith, P.T., Ma, S.M., Kaake, R., Wong, E.W., Xie, X., Li, J.W., Vederas, J.C., Tang, Y., Tsai, S.-C.
To be Published