CATH Domain 3gqiB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.505	SHC Adaptor Protein
	3.30.505.10	SH2 domain

Domain Context

CATH Clusters

Superfamily	SH2 domain
Functional Family	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Enzyme Information

3.1.4.11

Phosphoinositide phospholipase C.

based on mapping to UniProt P10686

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.

UniProtKB Entries (2)

P10686	PLCG1_RAT Rattus norvegicus 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
P11362	FGFR1_HUMAN Homo sapiens Fibroblast growth factor receptor 1

PDB Structure

PDB	3GQI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site. Bae, J.H., Lew, E.D., Yuzawa, S., Tome, F., Lax, I., Schlessinger, J. Cell(Cambridge,Mass.)