CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase

Enzyme Information

2.3.1.245
3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase.
based on mapping to UniProt P76143
Glycerone phosphate + acetyl-CoA = 3-hydroxy-5-phosphonooxypentane-2,4- dione + coenzyme A.
-!- The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2.

UniProtKB Entries (1)

P76143
LSRF_ECOLI
Escherichia coli K-12
3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase

PDB Structure

PDB 3GND
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The crystal structure of the Escherichia coli autoinducer-2 processing protein LsrF.
Diaz, Z., Xavier, K.B., Miller, S.T.
Plos One