CATH Domain 3g49A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Corticosteroid 11-beta-dehydrogenase isozyme 1

Enzyme Information

1.1.1.146

11-beta-hydroxysteroid dehydrogenase.

based on mapping to UniProt Q6QLL4

An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.

UniProtKB Entries (1)

DHI1_CAVPO

Cavia porcellus

Corticosteroid 11-beta-dehydrogenase isozyme 1

PDB Structure

PDB	3G49
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275. Siu, M., Johnson, T.O., Wang, Y., Nair, S.K., Taylor, W.D., Cripps, S.J., Matthews, J.J., Edwards, M.P., Pauly, T.A., Ermolieff, J., Castro, A., Hosea, N.A., LaPaglia, A., Fanjul, A.N., Vogel, J.E. Bioorg.Med.Chem.Lett.