CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoenolpyruvate-binding domains
Functional Family Pyruvate kinase

Enzyme Information

2.7.1.40
Pyruvate kinase.
based on mapping to UniProt P14618
ATP + pyruvate = ADP + phosphoenolpyruvate.
-!- UTP, GTP, CTP, ITP and dATP can also act as donors. -!- Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).

UniProtKB Entries (1)

P14618
KPYM_HUMAN
Homo sapiens
Pyruvate kinase PKM

PDB Structure

PDB 3G2G
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
S437Y Mutant of human muscle pyruvate kinase, isoform M2
Allali-Hassani, A., Hong, B., Dimov, S., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, c., Weigelt, J., Bochkarev, A., Park, H., Vedadi, M.
To be Published