CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family

Enzyme Information

2.1.1.179
16S rRNA (guanine(1405)-N(7))-methyltransferase.
based on mapping to UniProt Q763K9
S-adenosyl-L-methionine + guanine(1405) in 16S rRNA = S-adenosyl-L- homocysteine + N(7)-methylguanine(1405) in 16S rRNA.
-!- The enzyme from the antibiotic-producing bacterium Micromonospora zionensis specifically methylates guanine(1405) at N(7) in 16S rRNA, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins.

UniProtKB Entries (1)

Q763K9
Q763K9_ECOLX
Escherichia coli
16S rRNA (guanine(1405)-N(7))-methyltransferase

PDB Structure

PDB 3FRI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural bases for 16 S rRNA methylation catalyzed by ArmA and RmtB methyltransferases
Schmitt, E., Galimand, M., Panvert, M., Courvalin, P., Mechulam, Y.
J.Mol.Biol.