CATH Classification

Domain Context

CATH Clusters

Superfamily Tumor Necrosis Factor Receptor, subunit A, domain 2
Functional Family Ephrin type-A receptor 5

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P29317
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P29317
EPHA2_HUMAN
Homo sapiens
Ephrin type-A receptor 2

PDB Structure

PDB 3FL7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Architecture of Eph receptor clusters.
Himanen, J.P., Yermekbayeva, L., Janes, P.W., Walker, J.R., Xu, K., Atapattu, L., Rajashankar, K.R., Mensinga, A., Lackmann, M., Nikolov, D.B., Dhe-Paganon, S.
Proc.Natl.Acad.Sci.USA