CATH Classification

Domain Context

CATH Clusters

Superfamily Lipoxygenase-1; Domain 5
Functional Family Arachidonate 5-lipoxygenase a

Enzyme Information

1.13.11.40
Arachidonate 8-lipoxygenase.
based on mapping to UniProt O16025
Arachidonate + O(2) = (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14- tetraenoate.
-!- An enzyme from the coral Pseudoplexaura porosa.
4.2.1.92
Hydroperoxide dehydratase.
based on mapping to UniProt O16025
(9Z,11E,15Z)-(13S)-hydroperoxyoctadeca-9,11,15-trienoate = (9Z,15Z)- (13S)-12,13-epoxyoctadeca-9,11,15-trienoate + H(2)O.
-!- Acts on a number of unsaturated fatty-acid hydroperoxides, forming the corresponding allene oxides. -!- The product of the above reaction is unstable and is acted upon by EC 5.3.99.6 to form the cyclopentenone derivative (15Z)-12-oxophyto- 10,15-dienoate (OPDA), which is the first cyclic and biologically active metabolite in the jasmonate biosynthesis pathway.

UniProtKB Entries (1)

O16025
AOSL_PLEHO
Plexaura homomalla
Allene oxide synthase-lipoxygenase protein

PDB Structure

PDB 3FG3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity.
Neau, D.B., Gilbert, N.C., Bartlett, S.G., Boeglin, W., Brash, A.R., Newcomer, M.E.
Biochemistry