CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family Peptidyl-prolyl cis-trans isomerase FKBP1A

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P62942
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P42345
MTOR_HUMAN
Homo sapiens
Serine/threonine-protein kinase mTOR

PDB Structure

PDB 3FAP
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Liang, J., Choi, J., Clardy, J.
Acta Crystallogr.,Sect.D