CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphohistidine domain
Functional Family Phosphoenolpyruvate-protein phosphotransferase

Enzyme Information

2.7.3.9
Phosphoenolpyruvate--protein phosphotransferase.
based on mapping to UniProt P08839
Phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)- phospho-L-histidine.
-!- Acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9.5 kDa) involved in bacterial sugar transport. -!- A similar reaction where the protein is the enzyme EC 2.7.9.2 is part of the mechanism of that enzyme.

UniProtKB Entries (1)

P0AA04
PTHP_ECOLI
Escherichia coli K-12
Phosphocarrier protein HPr

PDB Structure

PDB 3EZB
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Solution structure of the 40,000 Mr phosphoryl transfer complex between the N-terminal domain of enzyme I and HPr.
Garrett, D.S., Seok, Y.J., Peterkofsky, A., Gronenborn, A.M., Clore, G.M.
Nat.Struct.Biol.