CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase S8/S53 domain
Functional Family Tripeptidyl-peptidase 1 preproprotein

Enzyme Information

3.4.14.9
Tripeptidyl-peptidase I.
based on mapping to UniProt O14773
Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity.
-!- A lysosomal enzyme that is active at acidic pH. -!- Belongs to peptidase family S53. -!- Formerly EC 3.4.14.8.

UniProtKB Entries (1)

O14773
TPP1_HUMAN
Homo sapiens
Tripeptidyl-peptidase 1

PDB Structure

PDB 3EDY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure and Autoactivation Pathway of the Precursor Form of Human Tripeptidyl-peptidase 1, the Enzyme Deficient in Late Infantile Ceroid Lipofuscinosis
Guhaniyogi, J., Sohar, I., Das, K., Stock, A.M., Lobel, P.
J.Biol.Chem.