CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Enzyme Information

2.6.1.105
Lysine--8-amino-7-oxononanoate transaminase.
based on mapping to UniProt P53555
L-lysine + 8-amino-7-oxononanoate = (S)-2-amino-6-oxohexanoate + 7,8- diaminononanoate.
-!- Participates in the pathway for biotin biosynthesis. -!- The enzyme from the bacterium Bacillus subtilis cannot use S-adenosyl-L-methionine as amino donor and catalyzes an alternative reaction for the conversion of 8-amino-7-oxononanoate to 7,8- diaminononanoate (cf. EC 2.6.1.62). -!- Formerly EC 2.6.1.n2.

UniProtKB Entries (1)

P53555
BIOK_BACSU
Bacillus subtilis subsp. subtilis str. 168
L-Lysine--8-amino-7-oxononanoate transaminase

PDB Structure

PDB 3DU4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
Dey, S., Lane, J.M., Lee, R.E., Rubin, E.J., Sacchettini, J.C.
Biochemistry