CATH Classification

Domain Context

CATH Clusters

Superfamily N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family Glyoxylate/succinic semialdehyde reductase 2

Enzyme Information

1.1.1.n11
Succinic semialdehyde reductase.
based on mapping to UniProt Q9LSV0
4-hydroxybutanoate + NADP(+) = succinate semialdehyde + NADPH.
1.1.1.79
Glyoxylate reductase (NADP(+)).
based on mapping to UniProt Q9LSV0
Glycolate + NADP(+) = glyoxylate + NADPH.
-!- Also reduces hydroxypyruvate to glycerate. -!- Has some affinity for NAD(+).

UniProtKB Entries (1)

Q9LSV0
GLYR1_ARATH
Arabidopsis thaliana
Glyoxylate/succinic semialdehyde reductase 1

PDB Structure

PDB 3DOJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cytosolic NADPH-dependent Glyoxylate Reductase from Arabidopsis: Crystal Structure and Kinetic Characterization of Active Site Mutants
Hoover, G., Jorgensen, R., Merrill, A.R., Shelp, B.J.
To be Published