CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Hepatocyte growth factor receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P08581
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08581
MET_HUMAN
Homo sapiens
Hepatocyte growth factor receptor

PDB Structure

PDB 3DKG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo.
Buchanan, S.G., Hendle, J., Lee, P.S., Smith, C.R., Bounaud, P.Y., Jessen, K.A., Tang, C.M., Huser, N.H., Felce, J.D., Froning, K.J., Peterman, M.C., Aubol, B.E., Gessert, S.F., Sauder, J.M., Schwinn, K.D., Russell, M., Rooney, I.A., Adams, J., Leon, B.C., Do, T.H., Blaney, J.M., Sprengeler, P.A., Thompson, D.A., Smyth, L., Pelletier, L.A., Atwell, S., Holme, K., Wasserman, S.R., Emtage, S., Burley, S.K., Reich, S.H.
Mol.Cancer Ther.