CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

2.6.1.7
Kynurenine--oxoglutarate transaminase.
based on mapping to UniProt Q8N5Z0
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
-!- Also acts on 3-hydroxykynurenine. -!- The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
2.6.1.39
2-aminoadipate transaminase.
based on mapping to UniProt Q8N5Z0
L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.

UniProtKB Entries (1)

Q8N5Z0
AADAT_HUMAN
Homo sapiens
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

PDB Structure

PDB 3DC1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II
Han, Q., Cai, T., Tagle, D.A., Robinson, H., Li, J.
Biosci.Rep.