CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Aurora kinase A

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P97477
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P97477
AURKA_MOUSE
Mus musculus
Aurora kinase A

PDB Structure

PDB 3DAJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry.
Cancilla, M.T., He, M.M., Viswanathan, N., Simmons, R.L., Taylor, M., Fung, A.D., Cao, K., Erlanson, D.A.
Bioorg.Med.Chem.Lett.