CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin

PDB Structure

PDB 3DA9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Compounds binding to the S2-S3 pockets of thrombin.
Nilsson, M., Hamalainen, M., Ivarsson, M., Gottfries, J., Xue, Y., Hansson, S., Isaksson, R., Fex, T.
J.Med.Chem.