CATH Classification

Domain Context

CATH Clusters

Superfamily Metal-dependent hydrolases
Functional Family

Enzyme Information

3.5.2.3
Dihydroorotase.
based on mapping to UniProt O66990
(S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate.

UniProtKB Entries (1)

O66990
PYRC_AQUAE
Aquifex aeolicus VF5
Dihydroorotase

PDB Structure

PDB 3D6N
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Dihydroorotase from the hyperthermophile Aquifiex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis.
Zhang, P., Martin, P.D., Purcarea, C., Vaishnav, A., Brunzelle, J.S., Fernando, R., Guy-Evans, H.I., Evans, D.R., Edwards, B.F.
Biochemistry