CATH Classification

Domain Context

CATH Clusters

Superfamily Creatinase/methionine aminopeptidase superfamily
Functional Family xaa-Pro aminopeptidase 1 isoform X1

Enzyme Information

3.4.11.9
Xaa-Pro aminopeptidase.
based on mapping to UniProt Q9NQW7
Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
-!- Generally membrane bound enzyme present in both mammalian and bacterial cells. -!- Belongs to peptidase family M24B.

UniProtKB Entries (1)

Q9NQW7
XPP1_HUMAN
Homo sapiens
Xaa-Pro aminopeptidase 1

PDB Structure

PDB 3CTZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit
Li, X., Lou, Z., Li, X., Zhou, W., Ma, M., Cao, Y., Geng, Y., Bartlam, M., Zhang, X.C., Rao, Z.
J.Biol.Chem.