CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family ATP-dependent DNA helicase

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt Q4JC68
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

Q4JC68
XPD_SULAC
Sulfolobus acidocaldarius DSM 639
ATP-dependent DNA helicase Saci_0192

PDB Structure

PDB 3CRV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations.
Fan, L., Fuss, J.O., Cheng, Q.J., Arvai, A.S., Hammel, M., Roberts, V.A., Cooper, P.K., Tainer, J.A.
Cell(Cambridge,Mass.)