CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family 2-hydroxy-3-oxopropionate reductase

Enzyme Information

1.1.1.291
2-hydroxymethylglutarate dehydrogenase.
based on mapping to UniProt Q0QLF5
(S)-2-hydroxymethylglutarate + NAD(+) = 2-formylglutarate + NADH.
-!- NADP(+) cannot replace NAD(+). -!- Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. -!- Other enzymes involved in this pathway are EC 1.17.1.5, EC 1.3.7.1, EC 3.5.2.18, EC 5.4.99.4, EC 5.3.3.6, EC 4.2.1.85 and EC 4.1.3.32.

UniProtKB Entries (1)

Q0QLF5
HMGD_EUBBA
Eubacterium barkeri
2-(hydroxymethyl)glutarate dehydrogenase

PDB Structure

PDB 3CKY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Kinetic Properties of a beta-Hydroxyacid Dehydrogenase Involved in Nicotinate Fermentation.
Reitz, S., Alhapel, A., Essen, L.O., Pierik, A.J.
J.Mol.Biol.