CATH Domain 3cduA03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.960	Mitochondrial Import Receptor Subunit Tom20; Chain A
	1.20.960.20

Domain Context

CATH Clusters

Superfamily	1.20.960.20
Functional Family	Genome polyprotein

Enzyme Information

3.6.1.15	Nucleoside-triphosphate phosphatase. based on mapping to UniProt P03313 NTP + H(2)O = NDP + phosphate. -!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
2.7.7.48	RNA-directed RNA polymerase. based on mapping to UniProt P03313 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
3.4.22.28	Picornain 3C. based on mapping to UniProt P03313 Selective cleavage of Gln-\|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. -!- From entero-, rhino-, aphto- and cardioviruses. -!- Larger than the homologous virus picornain 2A. -!- Belongs to peptidase family C3.
3.4.22.29	Picornain 2A. based on mapping to UniProt P03313 Selective cleavage of Tyr-\|-Gly bond in the picornavirus polyprotein. -!- From entero- and rhinoviruses. -!- Smaller than the homologous virus picornain 3C. -!- Belongs to peptidase family C3.

UniProtKB Entries (1)

POLG_CXB3N

Coxsackievirus B3 (strain Nancy)

Genome polyprotein

PDB Structure

PDB	3CDU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases Gruez, A., Selisko, B., Roberts, M., Bricogne, G., Bussetta, C., Jabafi, I., Coutard, B., De Palma, A.M., Neyts, J., Canard, B. J.Virol.