CATH Classification

Domain Context

CATH Clusters

Superfamily Exonuclease ExoI, domain 3
Functional Family Exodeoxyribonuclease I

Enzyme Information

3.1.11.1
Exodeoxyribonuclease I.
based on mapping to UniProt P04995
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
-!- Preference for single-stranded DNA. -!- The Escherichia coli enzyme hydrolyzes glucosylated DNA. -!- Similar enzymes; mammalian DNase III, exonuclease IV, T2- and T4-induced exodeoxyribonucleases. -!- Formerly EC 3.1.4.25.

UniProtKB Entries (2)

P04995
EX1_ECOLI
Escherichia coli K-12
Exodeoxyribonuclease I
A0A0H3GL04
A0A0H3GL04_KLEPH
Klebsiella pneumoniae subsp. pneumoniae HS11286
Single-stranded DNA-binding protein

PDB Structure

PDB 3C94
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of Escherichia coli single-stranded DNA-binding protein stimulation of exonuclease I.
Lu, D., Keck, J.L.
Proc.Natl.Acad.Sci.USA