CATH Classification

Domain Context

CATH Clusters

Superfamily Poly(A) polymerase predicted RNA binding domain
Functional Family Poly(A) polymerase

Enzyme Information

2.7.7.19
Polynucleotide adenylyltransferase.
based on mapping to UniProt P29468
ATP + RNA(n) = diphosphate + RNA(n+1).
-!- Also acts slowly with CTP. -!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group. -!- See also EC 2.7.7.6.

UniProtKB Entries (1)

P29468
PAP_YEAST
Saccharomyces cerevisiae S288C
Poly(A) polymerase

PDB Structure

PDB 3C66
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of yeast poly(A) polymerase in complex with a peptide from Fip1, an intrinsically disordered protein.
Meinke, G., Ezeokonkwo, C., Balbo, P., Stafford, W., Moore, C., Bohm, A.
Biochemistry