CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family G protein-coupled receptor kinase

Enzyme Information

2.7.11.14
Rhodopsin kinase.
based on mapping to UniProt P28327
ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.
-!- Acts on the bleached or activated form of rhodopsin. -!- Also phosphorylates the beta-adrenergic receptor, but more slowly. -!- Does not act on casein, histones or phosphovitin. -!- Inhibited by Zn(2+) and digitonin (cf. EC 2.7.11.15 and EC 2.7.11.16). -!- Formerly EC 2.7.1.97 and EC 2.7.1.125.

UniProtKB Entries (1)

P28327
RK_BOVIN
Bos taurus
Rhodopsin kinase

PDB Structure

PDB 3C50
External Links
Method X-RAY DIFFRACTION
Organism Trichoplusia
Primary Citation
Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation.
Singh, P., Wang, B., Maeda, T., Palczewski, K., Tesmer, J.J.
J.Biol.Chem.