CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Dihydroflavonol reductase

Enzyme Information

1.1.1.219
Dihydroflavanol 4-reductase.
based on mapping to UniProt P51110
A (2R,3S,4S)-leucoanthocyanidin + NADP(+) = a (2R,3R)-dihydroflavonol + NADPH.
-!- This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)- dihydromyricetin, although some enzymes may act only on a subset of these compounds. -!- Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4- diol. -!- NAD(+) can act instead of NADP(+), but more slowly.
1.1.1.234
Flavanone 4-reductase.
based on mapping to UniProt P51110
(2S)-flavan-4-ol + NADP(+) = (2S)-flavanone + NADPH.
-!- Involved in the biosynthesis of 3-deoxyanthocyanidins from flavanones such as naringenin or eriodictyol.

UniProtKB Entries (1)

P51110
DFRA_VITVI
Vitis vinifera
Dihydroflavonol 4-reductase

PDB Structure

PDB 3C1T
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural evidence for the inhibition of grape dihydroflavonol 4-reductase by flavonols
Trabelsi, N., Petit, P., Manigand, C., Langlois d'Estaintot, B., Granier, T., Chaudiere, J., Gallois, B.
Acta Crystallogr.,Sect.D