CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family L-tryptophan--pyruvate aminotransferase 1

Enzyme Information

2.6.1.99
L-tryptophan--pyruvate aminotransferase.
based on mapping to UniProt Q9S7N2
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine.
-!- This plant enzyme, along with EC 1.14.13.168, is responsible for the biosynthesis of the plant hormone indole-3-acetate from L-tryptophan.
2.6.1.27
Tryptophan transaminase.
based on mapping to UniProt Q9S7N2
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate.
-!- Also acts on 5-hydroxytryptophan and, to a lesser extent, on the phenyl amino acids.

UniProtKB Entries (1)

Q9S7N2
TAA1_ARATH
Arabidopsis thaliana
L-tryptophan--pyruvate aminotransferase 1

PDB Structure

PDB 3BWN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants
Tao, Y., Ferrer, J.L., Ljung, K., Pojer, F., Hong, F., Long, J.A., Li, L., Moreno, J.E., Bowman, M.E., Ivans, L.J., Cheng, Y., Lim, J., Zhao, Y., Ballare, C.L., Sandberg, G., Noel, J.P., Chory, J.
Cell(Cambridge,Mass.)