CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family Thymidylate synthase

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P0A884
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P0A884
TYSY_ECOLI
Escherichia coli K-12
Thymidylate synthase

PDB Structure

PDB 3BHL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Studies of Early Events in Catalysis by Thymidylate Synthase
Arendall III, W.B., Hyatt, D.C., Roberts, S.A., Weichsel, A., Dahlgren, A.L., Maley, F., Montfort, W.R.
To be Published