CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family Neuraminidase

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt Q9IGQ6
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

Q9IGQ6
NRAM_I18A0
Influenza A virus (A/Brevig Mission/1/1918(H1N1))
Neuraminidase

PDB Structure

PDB 3BEQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural characterization of the 1918 influenza virus H1N1 neuraminidase
Xu, X., Zhu, X., Dwek, R.A., Stevens, J., Wilson, I.A.
J.Virol.