CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Vascular endothelial growth factor receptor 2

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P35968
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P35968
VGFR2_HUMAN
Homo sapiens
Vascular endothelial growth factor receptor 2

PDB Structure

PDB 3BE2
External Links
Method X-RAY DIFFRACTION
Organism Trichoplusia
Primary Citation
Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation.
Harmange, J.C., Weiss, M.M., Germain, J., Polverino, A.J., Borg, G., Bready, J., Chen, D., Choquette, D., Coxon, A., Demelfi, T., Dipietro, L., Doerr, N., Estrada, J., Flynn, J., Graceffa, R.F., Harriman, S.P., Kaufman, S., La, D.S., Long, A., Martin, M.W., Neervannan, S., Patel, V.F., Potashman, M., Regal, K., Roveto, P.M., Schrag, M.L., Starnes, C., Tasker, A., Teffera, Y., Wang, L., White, R.D., Whittington, D.A., Zanon, R.
J.Med.Chem.