CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleotidyltransferases domain 2
Functional Family focal adhesion kinase 1 isoform X1

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q05397
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P01730
CD4_HUMAN
Homo sapiens
T-cell surface glycoprotein CD4

PDB Structure

PDB 3B71
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for the interaction between focal adhesion kinase and CD4.
Garron, M.L., Arthos, J., Guichou, J.F., McNally, J., Cicala, C., Arold, S.T.
J.Mol.Biol.