CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.50 | OB fold (Dihydrolipoamide Acetyltransferase, E2P) |
|
2.40.50.1010 |
Domain Context
CATH Clusters
| Superfamily | 2.40.50.1010 |
| Functional Family |
Enzyme Information
| 6.3.4.22 |
tRNA(Ile)(2)-agmatinylcytidine synthase.
based on mapping to UniProt O28025
ATP + agmatine + (tRNA(Ile)(2))-cytidine(34) + H(2)O = (tRNA(Ile)(2))-2- agmatinylcytidine(34) + AMP + 2 phosphate.
-!- The enzyme from the archaeon Archaeoglobus fulgidus modifies the wobble base of the CAU anticodon of the archaeal tRNA(Ile)(2) at the oxo group in position 2 of cytidine(34). -!- This modification is crucial for accurate decoding of the genetic code. -!- In bacteria EC 6.3.4.19, catalyzes the modification of (tRNA(Ile)(2))-cytidine(34) to (tRNA(Ile)(2))-lysidine(34).
|
UniProtKB Entries (1)
| O28025 |
TIAS_ARCFU
Archaeoglobus fulgidus DSM 4304
TRNA(Ile2) 2-agmatinylcytidine synthetase TiaS
|
PDB Structure
| PDB | 3AU7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis of tRNA agmatinylation essential for AUA codon decoding
Nat.Struct.Mol.Biol.
|